Blossom Russo is a highly intelligent and spunky teenager. The youngest of three, she lives with her divorced musician father, Nick, eldest brother and recovering substance abuser Anthony, and decidedly not-so-bright middle brother Joey. Along for the ride is Blossom's ditzy best friend, Six, who sometimes shows flashes of great perception.

• Mayim Bialik
• Joey Lawrence
• Michael Stoyanov
• Jenna Von Oÿ
• Ted Wass
• Finola Hughes
• Samaria Graham
• Courtney Chase