Loosely based on the 1984 B-horror comedy film The Toxic Avenger, Toxic Crusaders is a syndicated 13-episode animated series created by Lloyd Kaufman and Michael Herz. Like the source material, Toxie is a grotesque mutant endowed with superhuman powers, but is still a good-hearted and law-abiding citizen of the fictional town of Tromaville, New Jersey; the setting of most of Troma Entertainment's films. In a change from the films, the toxic waste mutated his mop into a sentient entity that sometimes battles enemies by itself or gives him ideas on how to solve problems. The villains include Czar Zosta, Dr. Killemoff, and Psycho, polluters from the planet Smogula who wreak ecological havoc with help from Tromaville's corrupt mayor, Grody. Bonehead, a street punk who bullied Melvin, joins them in the first episode.

• Rodger Bumpass
• Gregg Berger
• Susan Silo
• Ed Gilbert
• Hal Rayle
• Patric Zimmerman
• Chuck McCann
• Susan Blu