UFC Fight Night 272: Moicano vs. Duncan was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 4, 2026, at the Meta Apex in Enterprise, Nevada, part of the Las Vegas Valley, United States. A lightweight bout between former UFC Lightweight Championship challenger Renato Moicano and Chris Duncan headlined the event.

• Ultimate Fighting Championship
• Renato Moicano
• Chris Duncan
• Virna Jandiroba
• Tabatha Ricci
• Abdul-Rakhman Yakhyaev
• Brendson Ribeiro
• Ethyn Ewing
• Rafael Estevam